Note: The name of Aminex’s combination drug changed from PaBT to AMXT 1501/DFMO in August 2015. Earlier publications use the previous name, PaBT or Polyamine-Blocking Therapy. It was changed to AMXT 1501/DFMO to be more consistent with drug-naming convention. The drug itself is unchanged.
- Publication of collaborative research highlighting the immunosuppressive role of increased polyamines and the ability of AMXT 1501/DFMO to overcome this immune suppression. “Polyamine-Blocking Therapy Reverses Immunosuppression in the Tumor Microenvironment.” Hayes, C.S.; Shicora, A.C.; Keough, M.P.; Snook, A.E.; Burns, M.R.; and Gilmour, S.K. Cancer Immunology Research, 2014, 2(3), 274–85 (see http://www.ncbi.nlm.nih.gov/pubmed/24778323).
- Publication of collaborative research results demonstrating potential for using Aminex's AMXT 1501/DFMO for treatment of neuroblastoma. “AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport.” Samal, K.; Zhao, P.; Kendzicky, A.; Yco, L.P.; McClung, H.; Gerner, E.; Burns, M.; Bachmann, A.S.; and Sholler, G. Int. J. Cancer, 2013, 133(6), 1323–33 (see http://www.ncbi.nlm.nih.gov/pubmed/23457004).
- Publication of collaborative research confirming in predictive animal studies that AMXT 1501/DFMO has strong potential to be a major therapy for neuroblastoma, an early childhood nerve cancer with high mortality rates. "Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma." Gamble, L.; Hogarty, M.; Liu, X.; Ziegler, D.; Marshall, G.; Norris, M.; and Haber, M. Frontiers in Oncology: Cancer Molecular Targets and Therapeutics, 2012, 2 (11), 162, 1-10 (see http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499881/pdf/fonc-02-00162.pdf).
- Results from phase I/II trial using AMXT 1501/DFMO for oral cancers in house cats has been published. “Phase I/II clinical trial of 2-difluoromethylornithine (DFMO) and a novel polyamine transport inhibitor for feline oral squamous cell carcinoma.” . Skorupski, K.A.; O'Brien, T.G.; Guerrero, T.; Rodriguez, C.O., and Burns, M.R. Vet Comp Oncol. 2011, 9(4), 275–82 (see http://www.ncbi.nlm.nih.gov/pubmed/22077408).